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Protein Interactions Investigated by the Raman Spectroscopy for Biosensor Applications
R. P. Kengne-Momo,Ph. Daniel,F. Lagarde,Y. L. Jeyachandran,J. F. Pilard,M. J. Durand-Thouand,G. Thouand
International Journal of Spectroscopy , 2012, DOI: 10.1155/2012/462901
Abstract: Interaction and surface binding characteristics of staphylococcal protein A (SpA) and an anti-Escherichia coli immunoglobulin G (IgG) were studied using the Raman spectroscopy. The tyrosine amino acid residues present in the α-helix structure of SpA were found to be involved in interaction with IgG. In bulk interaction condition the native structure of proteins was almost preserved where interaction-related changes were observed in the overall secondary structure (α-helix) of SpA. In the adsorbed state, the protein structure was largely modified, which allowed the identification of tyrosine amino acids involved in SpA and IgG interaction. This study constitutes a direct Raman spectroscopic investigation of SpA and IgG (receptor-antibody) interaction mechanism in the goal of a future biosensor application for detection of pathogenic microorganisms. 1. Introduction Creating protein-protein and protein-surface interactions is the primary step of biological processes in bioimplants, bio-fouling, immunoassays, and biosensors [1]. Therefore, in the past few years, a great deal for research has been focussed on the understanding of the fundamental structure and physicochemical properties involved in these interactions [2, 3], because the applications are strongly connected in the good knowledge of these mechanisms. Structure and orientation changes are often a part of proteins interaction due to various factors such as specific/nonspecific attachment, hydration/dehydration, steric hindrance, competitive adsorption/desorption processes, and experimental conditions [4, 5]. However it appears that the protein interactions and their resulting structural conformations are very complicated processes. Facing protein interaction complexity, various analytical tools have been developed to characterize the exhibited different phenomena, physico-chemical behaviors, and interaction structures [4, 6–8]. Among these tools, the vibrational spectroscopic techniques, such as Raman spectroscopy, are considered as extremely useful tools to chemically and structurally investigate all material compounds, of which protein analysis now constitute a possible and interesting field of applications, more particularly, to determine secondary conformations and interaction structures [9–11]. Actually the Raman scattering technique is a vibrational molecular spectroscopy which, derives from an inelastic light scattering process. With the Raman spectroscopy, a laser photon is scattered by a sample molecule and loses (or gains) energy during the process. The amount of energy lost is seen as a
Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones
Malaichamy Jeyachandran,Penugonda Ramesh
Organic Chemistry International , 2011, DOI: 10.1155/2011/360810
Abstract: 2-(Arylsulfonyl)indane-1,3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1,3-dione, we have synthesized them (7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the presence of pyridine-piperidine medium for the first time. The synthesized 2-(arylsulfonyl)indane-1,3-diones were evaluated for antimicrobial and anticoagulant activities and all of them registered significant activity. 1. Introduction Indane-1,3-dione and its derivatives constitute a unique group of compounds and attracted the attention of organic chemists and biologist due to their three characteristic features [1, 2]. (a) Indane-1,3-diones have enormous synthetic potential due to the presence of β-dicarbonyl moiety which often serves as a synthon for the preparation of more structurally complex compounds via condensation, decomposition, reduction, cyclization, rearrangements, and so forth. (b) The molecule offers wide scope for the study of physiochemical properties such as 1,3-indandione tautomerism, dual reactivity, electrochemical redox properties, unique property of polycrystalline films, and quantum mechanical calculations, and so forth [3, 4]. (c) A wide range of biological properties covering antimicrobial, antitumor, anti-inflammatory, antiviral, antihepatitis, anticoagulant, rodenticidal, herbicidal, and insecticidal properties were associated with indane-1,3-dione derivatives [5–10]. A survey of literature revealed that derivatives of indane-1,3-dione particularly 2-arylsulfonylindane-1,3-diones have been found to be potent blood anticoagulants [11]. Earlier, these were prepared by the Claisen condensation involving diethyl phthalate and aryl methyl sulphones [12, 13] by a procedure analogous to the preparation of indane-1,3-dione from diethylphthalate and ethyl acetoacetate [14]. In search of improved oral anticoagulants, we have synthesized 2-(arylsulfonyl)indane-1,3-diones 7 a-f by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates. The reaction is based on the observation that phthalic anhydride can function as a carbonyl compound in Perkin-type reactions [15]. 2. Chemistry In an attempt to prepare improved analogs of 2-(arylsulfonyl)indane-1,3-diones, we have attempted the condensation of arylsulfonylacetic acids with phthalic anhydride under different conditions. Although, the reaction failed with
Blue rubber bleb nevus syndrome
Krishnappa Amita,Padmini Jeyachandran
Indian Journal of Pathology and Microbiology , 2010,
Abstract:
A case of fibrolipomatous hamartoma of the median nerve with macrodactyly
MN Suma, Padmini Jeyachandran, Sathish Arakeri
Internet Journal of Medical Update - EJOURNAL , 2012,
Abstract: Fibrolipomatous hamartoma of nerve is a tumor-like lipomatous process principally affecting young persons. The median nerve is most commonly involved. The lesion is characterized by a soft slowly growing mass, surrounding and infiltrating major nerves and their branches. It may cause symptoms of compression neuropathy and is associated with macrodactyly in one third of cases. Here, we present a case of Fibrolipomatous hamartoma of nerve in the wrist of a young man arising from median nerve. Debulking of the tumour was performed.
Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1,2,3-triazoles
Rajkumar Jeyachandran,Harish Kumar Potukuchi,Lutz Ackermann
Beilstein Journal of Organic Chemistry , 2012, DOI: 10.3762/bjoc.8.202
Abstract: Step-economical syntheses of annulated 1,2,3-triazoles were accomplished through copper-catalyzed intramolecular direct arylations in sustainable one-pot reactions. Thus, catalyzed cascade reactions involving [3 + 2]-azide–alkyne cycloadditions (CuAAC) and C–H bond functionalizations provided direct access to fully substituted 1,2,3-triazoles with excellent chemo- and regioselectivities. Likewise, the optimized catalytic system proved applicable to the direct preparation of 1,2-diarylated azoles through a one-pot C–H/N–H arylation reaction.
Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst
Jena Madhusmita,Shariff Shameem,Jeyachandran Padmini
Indian Journal of Pathology and Microbiology , 2010,
Abstract:
A case of fibrolipomatous hamartoma of the median nerve with macrodactyly
M N Suma,Padmini Jeyachandran,Sathish Arakeri
Internet Journal of Medical Update - EJOURNAL , 2012,
Abstract: Fibrolipomatous hamartoma of nerve is a tumor-like lipomatous process principally involving affecting young persons. The median nerve is most commonly affectedinvolved. The lesion is characterized by a soft slowly growing mass, surrounding and infiltrating major nerves and their branches. It may cause symptoms of compression neuropathy and is associated with macrodactyly in one third of cases. Here, we present a case of Fibrolipomatous hamartoma of nerve in the wrist of a young man arising from median nerve. Debulking of the tumour was performed.
Phytochemical Investigation of Ethnomedicinal Spermacoce ocymoides Roots
M. Jeyachandran,T. Anantha Kumar,S. Gandhimathi
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: The roots of S. ocymoides were exhaustively extracted with versatile solvents to get crude extracts, and were subjected to phytochemical analysis, UV and GCMS spectral data. The steroids and reducing sugars are present only in methanolic extract, whereas the phenolic compounds present almost all the extracts except the benzene extract; and the tannins present in benzene and methanolic extracts. Previous literature reveals that there are no tannins in aerial parts of S. ocymoides. In this present work tannins were found in roots of S. ocymoides. Both UV and GCMS analysis shows that there is mixture of components. With this view may helpful to search any new compounds from this part of the plant could be isolated hereafter, and the presence of tannins from S. ocymoides roots may helpful to future investigations of this plant.
Influence of Meta-Topolin on Efficient Plant Regeneration via Micropropagation and Organogenesis of Safflower (Carthamus tinctorius L.) cv. NARI-H-15  [PDF]
Jeyachandran Vijayakumar, Ponnirul Ponmanickam, P. Samuel, D. N. P. Sudarmani, J. Pandiarajan
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.84048
Abstract: The effect of meta-Topolin (mT) was assessed to develop a reliable protocol for efficient plant regeneration of safflower (Carthamus tinctorius L.) cv. NARI-H-15. For micropropagation, 7 - 9 days old shoot-tip explants cultured on MS basal medium supplemented with 3.0 mg/L meta-Topolin (mT) + 0.5 mg/L CPPU showed 97.7% adventitious shoot formation (42.4 shootlets) than node after 45 days of culture. For organogenesis, the seedling explants of immature leaf cultured on 1.5 mg/L CPPU or 1.5 mg/L NAA fortified medium produced high amount of callus than cotyledon and stem calli after 60 days of culture. However, MS basal medium fortified with 4.0 mg/L mT + 1.5 mg/L CPPU was found beneficial to stimulate 100% organogenic response (74.7 shootlets) from immature leaf calli than cotyledon and stem derived calli after 45 days of culture. The healthy plantlets obtained from micropropagation and organogenesis process cultured on 1/4 MS basal salts, 1.5% sucrose (w/v) and 0.8% agar (w/v) medium supplemented with NAA (1.5 mg/L) and mT (0.1 mg/L) produced maximum of 96% (12.8 rootlets) and 84% (7.3 rootlets) adventitious rooting, respectively than mT and CPPU tested medium. However, maximum of 67% and 42% survival rate was noticed when in vitro raised plants from micropropagation and organogenesis were hardened in pots containing soil mix and maintained under green house condition. This optimized regeneration protocol might be helpful in regeneration of new genotypes and cultivars of safflower to improve agronomic traits through in vitro selection process and Agrobacterium-mediated genetic transformation system.
Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
Mahesh, Ayyavu;Jeyachandran, Robert;Rao, Dowlathabad Muralidhara;Thangadurai, Devarajan;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2012005000081
Abstract: in the present study, the ethanolic root extract of desmodium gangeticum (l.) dc., fabaceae, (edg), have been studied in various acute and chronic ulcer mouse models. oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. in gastric ulcerated animal that received high dose of 150 mg/kg edg, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. pylorus ligated mice, pretreated with edg showed significant decrease in ulcerous activity under chronic condition. the highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. our results indicate that the edg possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.
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